A developmental switch in the response of DRG neurons to ETS transcription factor signaling. Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Spatial memory impairments following damage to the mediodorsal nucleus of the thalamus in rhesus monkeys. A subcortical inhibitory signal for behavioral arrest in the thalamus. Intralaminar and medial thalamic influence on cortical synchrony, information transmission and cognition. Anatomical and functional evidence for participation in processes of arousal and awareness. The intralaminar and midline nuclei of the thalamus. Requirement of prefrontal and midbrain regions for rapid executive control of behavior in the rat. Functional Connections of Cortical Areas: a New View from the Thalamus. Basal ganglia output to the thalamus: still a paradox. A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds. Context-dependent computation by recurrent dynamics in prefrontal cortex. The role of the basal ganglia in habit formation. Layer 4 fast-spiking interneurons filter thalamocortical signals during active somatosensation. Cell type-specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Immediate thalamic sensory plasticity depends on corticothalamic feedback. Thalamic control of sensory selection in divided attention. Distinct recurrent versus afferent dynamics in cortical visual processing. Procedures for behavioral experiments in head-fixed mice. A motor cortex circuit for motor planning and movement. Internally generated preactivation of single neurons in human medial frontal cortex predicts volition. What is the Bereitschaftspotential? Clin. Robust neuronal dynamics in premotor cortex during motor planning. Cognitive signals in the primate motor thalamus predict saccade timing. Ventral medial nucleus neurons send thalamocortical afferents more widely and more preferentially to layer 1 than neurons of the ventral anterior–ventral lateral nuclear complex in the rat. A comprehensive thalamocortical projection map at the mesoscopic level. A mesoscale connectome of the mouse brain. The afferent and efferent connections of the ventromedial thalamic nucleus in the rat. Decoding a perceptual decision process across cortex. Single neurons discharging before saccades. Memory related motor planning activity in posterior parietal cortex of macaque. Movement-related neuronal activity selectively coding either direction or muscle pattern in three motor areas of the monkey. Synaptic reverberation underlying mnemonic persistent activity. A cognitive signal for the proactive timing of action in macaque LIP. Decision making in recurrent neuronal circuits. Medial prefrontal activity during delay period contributes to learning of a working memory task. Neuronal correlates of parametric working memory in the prefrontal cortex. Mnemonic coding of visual space in the monkey’s dorsolateral prefrontal cortex. Neuron activity related to short-term memory. Neural antecedents of self-initiated actions in secondary motor cortex. A cortical substrate for memory-guided orienting in the rat. Flow of cortical activity underlying a tactile decision in mice. Cortical preparatory activity: representation of movement or first cog in a dynamical machine? Neuron 68, 387–400 (2010) Anticipatory activity of motor cortex neurons in relation to direction of an intended movement. Our results show that the thalamus is a circuit hub in motor preparation and suggest that persistent activity requires reciprocal excitation across multiple brain areas. Similarly, photoinhibition of the ALM diminished thalamic activity. Photoinhibition of the thalamus caused a short-latency and near-complete collapse of ALM activity. Unilateral photoinhibition of delay activity in the ALM or thalamus produced contralesional neglect. Here we show that, similar to ALM neurons, thalamic neurons exhibited selective persistent delay activity that predicted movement direction. We recorded spikes from the ALM and thalamus during tactile discrimination with a delayed directional response. The ALM is connected bidirectionally with parts of the thalamus, including the ventral medial and ventral anterior–lateral nuclei. Neurons in the mouse anterior lateral motor cortex (ALM) have been shown to have selective persistent activity that instructs future actions.
Models of persistent activity often invoke reverberations within local cortical circuits, but long-range circuits could also contribute. Persistent neural activity maintains information that connects past and future events.
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